Extracellular vesicles produced by bone marrow mesenchymal stem cells attenuate renal fibrosis, in part by inhibiting the RhoA/ROCK pathway, in a UUO rat model.

Z, Shi; Q, Wang; Y, Zhang; D, Jiang

doi:10.1186/s13287-020-01767-8

Public

Extracellular vesicles produced by bone marrow mesenchymal stem cells attenuate renal fibrosis, in part by inhibiting the RhoA/ROCK pathway, in a UUO rat model.

Shared by NobleBlocks on Jun 26, 2020 • 12:00 AM UTC

Authors:

Shi Z

Wang Q

Zhang Y

Abstract

Background Extracellular vesicles produced by bone marrow mesenchymal stem cells (BMSC-EVs) can play important roles in the repair of injured tissues. Though numerous studies have reported the effect of EVs on renal fibrosis, the underlying mechanisms remain unclear. We hypothesized that BMSC-EVs co...

Subject

Apoptosis

Oxidative stress

Renal interstitial fibrosis

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