ABC transporters and the hallmarks of cancer: roles in cancer aggressiveness beyond multidrug resistance

Muriithi, Wanjiru; Wanjiku Macharia, Lucy; Pilotto Heming, Carlos; Lima Echevarria, Juliana; Nyachieo, Atunga; Niemeyer Filho, Paulo; Moura‐Neto, Vivaldo

doi:10.20892/j.issn.2095-3941.2019.0284

Public

ABC transporters and the hallmarks of cancer: roles in cancer aggressiveness beyond multidrug resistance

Published in Cancer Biology and Medicine • Jan 1, 2020

Authors:

Wanjiru Muriithi

Lucy Wanjiku Macharia

Carlos Pilotto Heming

Abstract

The ATP-binding cassette transporters (ABC transporters) have been intensely studied over the past 50 years for their involvement in the multidrug resistance (MDR) phenotype, especially in cancer. They are frequently overexpressed in both naive and post-treatment tumors, and hinder effective chemoth...

Subject

ATP-binding cassette transporter

Multiple drug resistance

Cancer

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