Differential IRF8 Transcription Factor Requirement Defines Two Pathways of Dendritic Cell Development in Humans

Cytlak, Urszula; Resteu, Anastasia; Pagan, Sarah; Green, Kile; Milne, Paul; Maisuria, Sheetal; McDonald, David; Hulme, Gillian; Filby, Andrew; Carpenter, Benjamin; Queen, Rachel; Hambleton, Sophie; Hague, Rosie; Lango Allen, Hana; Thaventhiran, James; M. Doody, Gina; Collin, Matthew; Bigley, Venetia

doi:10.1016/j.immuni.2020.07.003

Public

Differential IRF8 Transcription Factor Requirement Defines Two Pathways of Dendritic Cell Development in Humans

Published in Immunity • Jul 30, 2020

Authors:

Urszula Cytlak

Anastasia Resteu

Sarah Pagan

Abstract

pre-DCs mapped exclusively to the DC2 pathway. In keeping with their lower requirement for IRF8, DC3s expand to replace DC2s in human partial IRF8 deficiency.

Subject

Biology

Transcription factor

IRF8

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