Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus

Korber, Bette; Fischer, Will; Gnanakaran, S.; Yoon, Hyejin; Theiler, James; Abfalterer, Werner; Hengartner, Nicolas; E. Giorgi, Elena; Bhattacharya, Tanmoy; Foley, Brian; M. Hastie, Kathryn; Parker, Matthew; G. Partridge, David; Evans, Cariad; M. Freeman, Timothy; I. de Silva, Thushan; Angyal, Adrienne; L. Brown, Rebecca; Carrilero, Laura; R. Green, Luke; C. Groves, Danielle; Johnson, Katie; J. Keeley, Alexander; B. Lindsey, Benjamin; J. Parsons, Paul; Raza, Mohammad; L. Rowland-Jones, Sarah; Smith, Darren; Tucker, Rachel; Wang, Dennis; D. Wyles, Matthew; McDanal, Charlene; G. Perez, Lautaro; Tang, Haili; Moon-Walker, Alex; P. J. Whelan, Sean; C. LaBranche, Celia; O. Saphire, Erica; C. Montefiori, David

doi:10.1016/j.cell.2020.06.043

Public

Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus

Published in Cell • Jul 2, 2020

Authors:

Bette Korber

Will Fischer

S. Gnanakaran

Abstract

A SARS-CoV-2 variant carrying the Spike protein amino acid change D614G has become the most prevalent form in the global pandemic. Dynamic tracking of variant frequencies revealed a recurrent pattern of G614 increase at multiple geographic levels: national, regional, and municipal. The shift occurre...

Subject

Biology

Infectivity

Spike (software development)

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!