Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis

C. Habermann, Arun; J. Gutierrez, Austin; T. Bui, Linh; L. Yahn, Stephanie; I. Winters, Nichelle; L. Calvi, Carla; Peter, Lance; Chung, Mei-I; J. Taylor, Chase; S. Jetter, Christopher; Raju, Latha; Roberson, Jamie; Ding, Guixiao; Wood, Lori; M. S. Sucre, Jennifer; W. Richmond, Bradley; Serezani, Ana; J. McDonnell, Wyatt; B. Mallal, Simon; J. Bacchetta, Matthew; E. Loyd, James; M. Shaver, Ciara; B. Ware, Lorraine; M. Bremner, Ross; Walia, Rajat; S. Blackwell, Timothy; E. Banovich, Nicholas; A. Kropski, Jonathan

doi:10.1126/sciadv.aba1972

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Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis

Published in Science Advances • Jul 8, 2020

Authors:

Arun C. Habermann

Austin J. Gutierrez

Linh T. Bui

Abstract

pathologic, ECM-producing epithelial cell population that was highly enriched in PF lungs. Multiple fibroblast subtypes were observed to contribute to ECM expansion in a spatially discrete manner. Together, these data provide high-resolution insights into the complexity and plasticity of the distal ...

Subject

Mesenchymal stem cell

RNA

Biology

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