Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis

Adams, Taylor; C. Schupp, Jonas; Poli, Sergio; Ayaub, Ehab; Neumark, Nir; Ahangari, Farida; Chu, Sarah; A. Raby, Benjamin; DeIuliis, Giuseppe; Januszyk, Michael; Duan, Qiaonan; A. Arnett, Heather; Siddiqui, Asim; R. Washko, George; Homer, Robert; Yan, Xiting; O. Rosas, Iván; Kaminski, Naftali

doi:10.1126/sciadv.aba1983

Public

Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis

Published in Science Advances • Jul 8, 2020

Authors:

Taylor Adams

Jonas C. Schupp

Sergio Poli

Abstract

We provide a single-cell atlas of idiopathic pulmonary fibrosis (IPF), a fatal interstitial lung disease, by profiling 312,928 cells from 32 IPF, 28 smoker and nonsmoker controls, and 18 chronic obstructive pulmonary disease (COPD) lungs. Among epithelial cells enriched in IPF, we identify a previou...

Subject

Lung

Pulmonary fibrosis

Cell

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!