Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients.

Hadjadj, Jérôme; Yatim, Nader; Barnabei, Laura; Corneau, Aurélien; Boussier, Jeremy; Smith, Nikaïa; Péré, Hélène; Charbit, Bruno; Bondet, Vincent; Chenevier-Gobeaux, Camille; Breillat, Paul; Carlier, Nicolas; Gauzit, Rémy; Morbieu, Caroline; Pène, Frédéric; Marin, Nathalie; Roche, Nicolas; Szwebel, Tali-Anne; H Merkling, Sarah; Treluyer, Jean-Marc; Veyer, David; Mouthon, Luc; Blanc, Catherine; Tharaux, Pierre-Louis; Rozenberg, Flore; Fischer, Alain; Duffy, Darragh; Rieux-Laucat, Frédéric; Kernéis, Solen; Terrier, Benjamin

doi:10.1126/science.abc6027

Public

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients.

Shared by NobleBlocks on Aug 7, 2020 • 12:00 AM UTC

Authors:

Jérôme Hadjadj

Nader Yatim

Laura Barnabei

Abstract

Coronavirus disease 2019 (COVID-19) is characterized by distinct patterns of disease progression that suggest diverse host immune responses. We performed an integrated immune analysis on a cohort of 50 COVID-19 patients with various disease severity. A distinct phenotype was observed in severe and c...

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