Bone marrow mesenchymal stem cell-derived exosomes protect cartilage damage and relieve knee osteoarthritis pain in a rat model of osteoarthritis

He, Lei; He, Tianwei; Xing, Jianghao; Zhou, Qing; Fan, Lei; Liu, Can; Chen, Yuyong; Wu, Depeng; Tian, Zhenming; Liu, Bin; Rong, Limin

doi:10.1186/s13287-020-01781-w

Public

Bone marrow mesenchymal stem cell-derived exosomes protect cartilage damage and relieve knee osteoarthritis pain in a rat model of osteoarthritis

Published in Stem Cell Research & Therapy • Jul 10, 2020

Authors:

Lei He

Tianwei He

Jianghao Xing

Abstract

BACKGROUND: This study aimed to investigate the effect of bone marrow mesenchymal stem cell (BMSC)-derived exosome injection on cartilage damage and pain relief in both in vitro and in vivo models of osteoarthritis (OA). METHODS: The BMSCs were extracted from rat bone marrow of the femur and tibia. ...

Subject

Osteoarthritis

Mesenchymal stem cell

Medicine

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