Ibrutinib for improved chimeric antigen receptor T‐cell production for chronic lymphocytic leukemia patients

Fan, Fuli; Joo Yoo, Hyeon; Stock, Sophia; Wang, Lei; Liu, Yibin; Schubert, Maria‐Luisa; Wang, Sanmei; Neuber, Brigitte; Hückelhoven‐Krauss, Angela; Gern, Ulrike; Schmitt, Anita; Müller‐Tidow, Carsten; Dreger, Peter; Schmitt, Michael; Sellner, Leopold

doi:10.1002/ijc.33212

Public

Ibrutinib for improved chimeric antigen receptor T‐cell production for chronic lymphocytic leukemia patients

Published in International Journal of Cancer • Jul 19, 2020

Authors:

Fuli Fan

Hyeon Joo Yoo

Sophia Stock

Abstract

Chimeric antigen receptor T (CART) cells targeting CD19 have shown promising results in the treatment of chronic lymphocytic leukemia (CLL). However, efficacy seems to be inferior compared to diffuse large B-cell lymphoma or acute lymphoblastic leukemia. Impaired T-cell fitness of CLL patients may b...

Subject

Ibrutinib

Chronic lymphocytic leukemia

Chimeric antigen receptor

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