Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial

M. Folegatti, Pedro; Ewer, Katie; K. Aley, Parvinder; Angus, Brian; Becker, Stephan; Belij‐Rammerstorfer, Sandra; Bellamy, Duncan; Bibi, Sagida; Bittaye, Mustapha; Clutterbuck, Elizabeth; Dold, Christina; N. Faust, Saul; Finn, Adam; Flaxman, Amy; Hallis, Bassam; T. Heath, Paul; Jenkin, Daniel; Lazarus, Rajeka; Makinson, Rebecca; M. Minassian, Angela; M. Pollock, Katrina; Ramasamy, Maheshi; Robinson, Hannah; D. Snape, Matthew; Tarrant, Richard; Voysey, Merryn; Green, Catherine; D. Douglas, Alexander; V. S. Hill, Adrian; Lambe, Teresa; C. Gilbert, Sarah; J. Pollard, Andrew; Aboagye, Jeremy; F. Adams, K.; Ali, Aabidah; Allen, Elizabeth; L. Allison, Jennifer; Anslow, Rachel; H. Arbe-Barnes, Edward; Babbage, Gavin; Kenneth Baillie, J.; Baker, Megan; Baker, Natalie; Baker, Philip; Baleanu, Ioana; Ballaminut, Juliana; Barnes, Eleanor; R. Barrett, Jordan; Bates, Louise; Batten, Alexander; Beadon, Kirsten; Beckley, Rebecca; Berrie, Eleanor; Berry, Lisa; Beveridge, Amy; R. Bewley, Kevin; M. Bijker, Else; Bingham, Tracey; Blackwell, Luke; L. Blundell, Caitlin; Bolam, Emma; Boland, Elena; Borthwick, Nicola; Bower, Thomas; Boyd, Amy; Brenner, Tanja; Bright, Philip; Brown-O’Sullivan, Charlie; Brunt, Emily; Burbage, Jamie; Burge, Sharon; R. Buttigieg, Karen; Byard, Nicholas; Cabera Puig, Ingrid; Calvert, Anna; Camara, Susana; Cao, Michelangelo; Cappuccini, Federica; Carr, Melanie; W. Carroll, Miles; Carter, Victoria; Cathie, Katrina; Challis, Ruth; Charlton, Sue; Chelysheva, Irina; Cho, Jee-Sun; Cicconi, Paola; Cifuentes, Liliana; Clark, Helen; Clark, Elizabeth; Cole, Tom; Colin-Jones, Rachel; P. Conlon, Christopher; Cook, Aislinn; S. Coombes, Naomi; Cooper, Rachel; A. Cosgrove, Catherine; Coy, Karen; E.M. Crocker, Wendy; J. Cunningham, Christina; E. Damratoski, Brad; Dando, Lynne; S. Datoo, Mehreen; Dele Davies, H.; de Graaf, Hans; Demissie, Tesfaye; Di Maso, Claudio; Dietrich, Isabelle; Dong, Tao; R. Donnellan, Francesca; Douglas, Naomi; Downing, Charlotte; Drake, Jonathan; Drake-Brockman, Rachael; Drury, Ruth; Dunachie, Susanna; J. Edwards, Nick; D.L. Edwards, Frances; J Edwards, C; C. Elias, Sean; J. Elmore, Michael; R. W. Emary, Katherine; Rex English, Marcus; Fagerbrink, Susanne; Felle, Sally; Feng, Shuo; Field, Samantha; Fixmer, Carine; Fletcher, Clare; Ford, Karen; Fowler, Jamie; Fox, Polly; Francis, Emma; Frater, John; Furze, Julie; Fuskova, Michelle; Galiza, Eva; Gbesemete, Diane; Gilbride, Ciarán; Godwin, Kerry; Gorini, Giacomo; Goulston, Lyndsey; Grabau, Caroline; Gracie, Lara; Gray, Zoe; Belle Guthrie, Lucy; J. Hackett, Mark; Halwe, Sandro; Hamilton, Elizabeth; Hamlyn, Joseph; Hanumunthadu, Brama; Harding, Irasha; A. Harris, Stephanie; R. Harris, Andrew; Harrison, Daisy; Harrison, C.P.; C. Hart, Thomas; Haskell, Louise; Hawkins, Sophia; M. Head, Ian; A. Henry, John; Hill, Jennifer; H. Hodgson, Susanne; M. Hou, Mimi; Howe, Elizabeth; Howell, Nicola; Hutlin, Cecilia; Ikram, Sabina; Isitt, Catherine; Iveson, Poppy; Jackson, Susan; Jackson, Frederic; James, William; Jenkins, Megan; Jones, Elizabeth; Jones, Kathryn; E. Jones, Christine; A. Jones, Bryony; Kailath, Reshma; Karampatsas, Konstantinos; Keen, Jade; Kelly, Sarah; Kelly, Dearbhla; Kerr, David; Kerridge, Simon; Khan, Liaquat; Khan, Uzma; Killen, Annabel; Kinch, Jasmin; B. King, Thomas; D. W. King, Lloyd; King, Jade; Kingham-Page, Lucy; Klenerman, Paul; Knapper, Francesca; C. Knight, Julian; Knott, Daniel; Koleva, Stanislava; Kupke, Alexandra; W. Larkworthy, Colin; P. J. Larwood, Jessica; Laskey, Anna; M. Lawrie, Alison; Lee, Arlene; Yee Ngan Lee, Kim; A. Lees, Emily; Legge, Helen; Lelliott, Alice; Lemm, Nana‐Marie; M. Lias, Amelia; Linder, Aline; Lipworth, Samuel; Liu, Xinxue; Liu, Shuchang; Lopez Ramon, Raquel; Lwin, May; Mabesa, Francesca; Madhavan, Meera; Mallett, Garry; Mansatta, Kushal; Marcal, Ines; Marinou, Spyridoula; Marlow, Emma; L. Marshall, Julia; Martin, Jane; McEwan, Joanne; McInroy, Lorna; Meddaugh, Gretchen; J. Mentzer, Alexander; Mirtorabi, Neginsadat; Moore, Maria; C. Moran, Edward; Morey, Ella; Morgan, Victoria; Morris, Susan; Morrison, Hazel; Morshead, Gertraud; Morter, Richard; F Mujadidi, Yama; Muller, Jilly; Múnera‐Huertas, Tatiana; Munro, Claire; Munro, Alasdair; Murphy, Sarah; J. Munster, Vincent; Mweu, Philomena; Noé, Andrés; L. Nugent, Fay; Nuthall, Elizabeth; M. O’Brien, Katie; O’Connor, Daniel; Oguti, Blanché; L. Oliver, Jennifer; Oliveira, Catarina; O’Reilly, Peter; Osborn, Mairead; Osborne, Piper; Owen, Cathy; Owens, DR; Owino, Nelly; Pacurar, Mihaela; Parker, Kaye; Parracho, Helena; Patrick-Smith, Maia; Payne, Victoria; Pearce, Jennifer; Peng, Yanchun; Polo Peralta Álvarez, Marco; Perring, James; Pfafferott, Katja; Pipini, Dimitra; Plested, Emma; Pluess-Hall, Helen; M. Pollock, Katrina; Poulton, Ian; Presland, Laura; Provstgaard-Morys, Samuel; Pulido, David; Radia, Kajal; Ramos Lopez, Fernando; Rand, Jade; Ratcliffe, Helen; A. Rawlinson, Thomas; Rhead, Sarah; Riddell, Amy; Ritchie, Adam; Roberts, Hannah; Robson, Joanna; Roche, Sophie; Rohde, Cornelius; S. Rollier, Christine; Romani, Rossana; Rudiansyah, Indra; Saich, Stephen; Sajjad, Sara; Salvador, Stephannie; Sànchez-Riera, Lídia; Sanders, Helen; Sanders, Katherine; Sapaun, Shari; Sayce, Chloe; Schofield, Ella; Screaton, Gavin; Selby, B.; Semple, Calum; R. Sharpe, Hannah; H. Shaik, Imam; Shea, Adam; Shelton, Holly; E. Silk, Sarah; Silva-Reyes, Laura; Skelly, Donal; Smee, Heather; C. Smith, Catherine; J. Smith, David; Song, Rinn; J. Spencer, Alexandra; Stafford, Elizabeth; Steele, Amy; Stefanova, Elena; Stockdale, Lisa; Szigeti, Anna; Tahiri‐Alaoui, Abdessamad; Tait, Moira; Keipp Talbot, H.; Tanner, Rachel; J. Taylor, Iona; M. Taylor, Victoria; te Water Naudé, Rebecca; Thakur, Nazia; Themistocleous, Yrene; C. Themistocleous, Andreas; Thomas, Merin; M. Thomas, Tonia; Thompson, Amber; Thomson-Hill, Samantha; Tomlins, Jennifer; Tonks, Susan; Towner, James; Tran, Nguyen; A. Tree, Julia; Truby, Adam; Turkentine, Kate; Turner, Cheryl; Turner, Nicola; Turner, Sally; Tuthill, Toby; Ulaszewska, Marta; Varughese, Rachel; van Doremalen, Neeltje; Veighey, Kristin; K. Verheul, Marije; Vichos, Iason; Vitale, Elia; M. Walker, Laura; Watson, Marion; Welham, Benjamin; Wheat, Julie; White, Caroline; White, Rachel; Worth, Andrew; Wright, Danny; E Wright, Suzie; Li Yao, Xin; Yau, Yasmine

doi:10.1016/s0140-6736(20)31604-4

Public

Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial

Published in The Lancet • Jul 20, 2020

Authors:

Pedro M. Folegatti

Katie Ewer

Parvinder K. Aley

Abstract

Background The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) might be curtailed by vaccination. We assessed the safety, reactogenicity, and immunogenicity of a viral vectored coronavirus vaccine that expresses the spike protein of SARS-CoV-2. Methods We did a phase 1/2, si...

Subject

Reactogenicity

Immunogenicity

Medicine

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