Discovery and Genomic Characterization of a 382-Nucleotide Deletion in ORF7b and ORF8 during the Early Evolution of SARS-CoV-2

C. F. Su, Yvonne; E. Anderson, Danielle; Edward Young, Barnaby; Linster, Martin; Zhu, Feng; Jayakumar, Jayanthi; Zhuang, Yan; Kalimuddin, Shirin; G. Low, Jenny; Wah Tan, Chee; Ni Chia, Wan; Minn Mak, Tze; Octavia, Sophie; Chavatte, Jean‐Marc; Tze Chuen Lee, Raphael; Pada, Surinder; Yen Tan, Seow; Sun, Louisa; Yan, Gabriel; Maurer‐Stroh, Sebastian; H. Mendenhall, Ian; Leo, Yee‐Sin; Chien Lye, David; Wang, Lin‐Fa; J. D. Smith, Gavin

doi:10.1128/mbio.01610-20

Public

Discovery and Genomic Characterization of a 382-Nucleotide Deletion in ORF7b and ORF8 during the Early Evolution of SARS-CoV-2

Published in mBio • Jul 20, 2020

Authors:

Yvonne C. F. Su

Danielle E. Anderson

Barnaby Edward Young

Abstract

During the SARS epidemic in 2003/2004, a number of deletions were observed in ORF8 of SARS-CoV, and eventually deletion variants became predominant, leading to the hypothesis that ORF8 was an evolutionary hot spot for adaptation of SARS-CoV to humans. However, due to the successful control of the SA...

Subject

Biology

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Virology

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