Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis

D Nassar, Zeyad; Yan Mah, Chui; Dehairs, Jonas; JG Burvenich, Ingrid; Irani, Swati; M Centenera, Margaret; Helm, Madison; K Shrestha, Raj; Moldovan, Max; S Don, Anthony; Holst, Jeff; M Scott, Andrew; G Horvath, Lisa; J Lynn, David; A Selth, Luke; J Hoy, Andrew; V Swinnen, Johannes; M Butler, Lisa

doi:10.7554/elife.54166

Public

Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis

Shared by NobleBlocks on Jul 20, 2020 • 12:00 AM UTC

Authors:

Zeyad D Nassar

Chui Yan Mah

Jonas Dehairs

Abstract

Fatty acid β-oxidation (FAO) is the main bioenergetic pathway in human prostate cancer (PCa) and a promising novel therapeutic vulnerability. Here we demonstrate therapeutic efficacy of targeting FAO in clinical prostate tumors cultured ex vivo, and identify DECR1, encoding the rate-limiting enzyme ...

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