Multi-faceted epigenetic dysregulation of gene expression promotes esophageal squamous cell carcinoma.

W, Cao; H, Lee; W, Wu; A, Zaman; S, McCorkle; M, Yan; J, Chen; Q, Xing; N, Sinnott-Armstrong; H, Xu; MR, Sailani; W, Tang; Y, Cui; J, Liu; H, Guan; P, Lv; X, Sun; L, Sun; P, Han; Y, Lou; J, Chang; J, Wang; Y, Gao; J, Guo; G, Schenk; AH, Shain; FG, Biddle; E, Collisson; M, Snyder; TG, Bivona

doi:10.1038/s41467-020-17227-z

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Multi-faceted epigenetic dysregulation of gene expression promotes esophageal squamous cell carcinoma.

Shared by NobleBlocks on Jul 22, 2020 • 12:00 AM UTC

Authors:

Cao W

Lee H

Wu W

Abstract

Epigenetic landscapes can shape physiologic and disease phenotypes. We used integrative, high resolution multi-omics methods to delineate the methylome landscape and characterize the oncogenic drivers of esophageal squamous cell carcinoma (ESCC). We found 98% of CpGs are hypomethylated across the ES...

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