Naturally Derived Heme-Oxygenase 1 Inducers and Their Therapeutic Application to Immune-Mediated Diseases.

Samanta C, Funes,; Mariana, Rios,; Ayleen, Fernández-Fierro,; Camila, Covián,; Susan M, Bueno,; Claudia A, Riedel,; Juan Pablo, Mackern-Oberti,; Alexis M, Kalergis,

doi:10.3389/fimmu.2020.01467

Public

Naturally Derived Heme-Oxygenase 1 Inducers and Their Therapeutic Application to Immune-Mediated Diseases.

Published in Frontiers in immunology • Jan 1, 2020

Authors:

Funes, Samanta C

Rios, Mariana

Fernández-Fierro, Ayleen

Abstract

Heme oxygenase (HO) is the primary antioxidant enzyme involved in heme group degradation. A variety of stimuli triggers the expression of the inducible HO-1 isoform, which is modulated by its substrate and cellular stressors. A major anti-inflammatory role has been assigned to the HO-1 activity. The...

Subject

HO-1

autoimmunity

heme oxygenase 1

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