Mapping functional humoral correlates of protection against malaria challenge following RTS,S/AS01 vaccination

J. Suscovich, Todd; K. Fallon, Jonathan; Das, Jishnu; Demas, Allison; A. Crain, Jonathan; Linde, Caitlyn; R. Michell, Ashlin; Natarajan, Harini; P. Arevalo, Claudia; Broge, Thomas; C. Linnekin, Thomas; Kulkarni, Viraj; Lu, Richard; D. Slein, Matthew; Luedemann, Corinne; Marquette, Meghan; March, Sandra; A. Weiner, Joshua; Gregory, Scott; Coccia, Margherita; Flores-García, Yevel; Zavala, Fidel; E. Ackerman, Margaret; S. Bergmann‐Leitner, Elke; Hendriks, Jenny; Sadoff, Jerald; Dutta, Sheetij; N. Bhatia, Sangeeta; A. Lauffenburger, Douglas; Jongert, Erik; Wille-Reece, Ulrike; Alter, Galit

doi:10.1126/scitranslmed.abb4757

Public

Mapping functional humoral correlates of protection against malaria challenge following RTS,S/AS01 vaccination

Published in Science Translational Medicine • Jul 22, 2020

Authors:

Todd J. Suscovich

Jonathan K. Fallon

Jishnu Das

Abstract

Vaccine development has the potential to be accelerated by coupling tools such as systems immunology analyses and controlled human infection models to define the protective efficacy of prospective immunogens without expensive and slow phase 2b/3 vaccine studies. Among human challenge models, control...

Subject

Vaccination

Malaria

Immunology

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!