Structural effects of the highly protective V127 polymorphism on human prion protein

L. P. Hosszu, Laszlo; Conners, Rebecca; Sangar, Daljit; Batchelor, Mark; B. Sawyer, Elizabeth; Fisher, Stuart; J. Cliff, Matthew; M. Hounslow, Andrea; McAuley, Katherine; Brady, R.L.; S. Jackson, Graham; Bieschke, Jan; P. Waltho, Jonathan; Collinge, John

doi:10.1038/s42003-020-01126-6

Public

Structural effects of the highly protective V127 polymorphism on human prion protein

Published in Communications Biology • Jul 29, 2020

Authors:

Laszlo L. P. Hosszu

Rebecca Conners

Daljit Sangar

Abstract

Prion diseases, a group of incurable, lethal neurodegenerative disorders of mammals including humans, are caused by prions, assemblies of misfolded host prion protein (PrP). A single point mutation (G127V) in human PrP prevents prion disease, however the structural basis for its protective effect re...

Subject

Prion protein

Transmissible spongiform encephalopathy

Point mutation

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