Adaptation of SARS-CoV-2 in BALB/c mice for testing vaccine efficacy

Gu, Hongjing; Chen, Qi; Yang, Guan; He, Lei; Fan, Hang; Deng, Yong‐Qiang; Wang, Yanxiao; Teng, Yue; Zhao, Zhongpeng; Cui, Yujun; Li, Yuchang; Li, Xiao-Feng; Li, Jiangfan; Zhang, Na-Na; Yang, Xiaolan; Chen, Shaolong; Guo, Yan; Zhao, Guangyu; Wang, Xiliang; Luo, Deyan; Wang, Hui; Yang, Xiao; Li, Yan; Han, Gencheng; He, Yuxian; Zhou, Xiaojun; Geng, Shusheng; Sheng, Xiaoli; Jiang, Shibo; Sun, Shihui; Qin, Cheng‐Feng; Zhou, Yusen

doi:10.1126/science.abc4730

Public

Adaptation of SARS-CoV-2 in BALB/c mice for testing vaccine efficacy

Published in Science • Jul 30, 2020

Authors:

Hongjing Gu

Qi Chen

Guan Yang

Abstract

The ongoing coronavirus disease 2019 (COVID-19) pandemic has prioritized the development of small-animal models for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We adapted a clinical isolate of SARS-CoV-2 by serial passaging in the respiratory tract of aged BALB/c mice. The resultin...

Subject

Virology

Coronavirus

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

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