LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/β-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes

Zhou, Cefan; Yi, Changhua; Yi, Yongxiang; Qin, Wenying; Yan, Yanan; Dong, Xueying; Zhang, Xuewen; Huang, Yuan; Zhang, Rui; Wei, Jie; W. Ali, Declan; Michalak, Marek; Chen, Xing‐Zhen; Tang, Jingfeng

doi:10.1186/s12943-020-01237-y

Public

LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/β-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes

Published in Molecular Cancer • Jul 29, 2020

Authors:

Cefan Zhou

Changhua Yi

Yongxiang Yi

Abstract

BACKGROUND: Pancreatic cancer is one of the most lethal malignancies and has an extremely poor diagnosis and prognosis. The development of resistance to gemcitabine is still a major challenge. The long noncoding RNA PVT1 was reported to be involved in carcinogenesis and chemoresistance; however, the...

Subject

Wnt signaling pathway

Autophagy

Cancer research

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