Atrial Myocyte NLRP3/CaMKII Nexus Forms a Substrate for Postoperative Atrial Fibrillation

Heijman, Jordi; Phina Muna, Azinwi; Veleva, Tina; E. Molina, Cristina; Sutanto, Henry; Tekook, Marcel; Wang, Qiongling; Abu-Taha, Issam; Gorka, Marcel; R. Künzel, Stephan; El‐Armouche, Ali; Reichenspurner, Hermann; Kamler, Markus; O. Nikolaev, Viacheslav; Ravens, Ursula; Li, Na; Nattel, Stanley; H.T. Wehrens, Xander; Dobrev, Dobromir

doi:10.1161/circresaha.120.316710

Public

Atrial Myocyte NLRP3/CaMKII Nexus Forms a Substrate for Postoperative Atrial Fibrillation

Published in Circulation Research • Jul 30, 2020

Authors:

Jordi Heijman

Azinwi Phina Muna

Tina Veleva

Abstract

Rationale: Postoperative atrial fibrillation (POAF) is a common and troublesome complication of cardiac surgery. POAF is generally believed to occur when postoperative triggers act on a preexisting vulnerable substrate, but the underlying cellular and molecular mechanisms are largely unknown. Object...

Subject

Ryanodine receptor 2

Phospholamban

Ryanodine receptor

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