Short-Chain Fatty Acids Ameliorate Diabetic Nephropathy via GPR43-Mediated Inhibition of Oxidative Stress and NF-<i>κ</i>B Signaling

Huang, Wei; Man, Yi; Gao, Chenlin; Zhou, Luping; Gu, Junling; Xu, Huiwen; Qin, Wan; Long, Yang; Chai, Li; Xu, Youhua; Xu, Yong

doi:10.1155/2020/4074832

Public

Short-Chain Fatty Acids Ameliorate Diabetic Nephropathy via GPR43-Mediated Inhibition of Oxidative Stress and NF-κB Signaling

Published in Oxidative Medicine and Cellular Longevity • Aug 3, 2020

Authors:

Wei Huang

Yi Man

Chenlin Gao

Abstract

Diabetic nephropathy (DN) is a chronic low-grade inflammatory disease. Oxidative stress and nuclear factor kappa B (NF- κ B) signaling play an important role in the pathogenesis of DN. Short-chain fatty acids (SCFAs) produced from carbohydrate fermentation in the gastrointestinal tract exert positiv...

Subject

Oxidative stress

Butyrate

Diabetic nephropathy

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!