An integrative multi-omics analysis to identify candidate DNA methylation biomarkers related to prostate cancer risk

Wu, Lang; Yang, Yaohua; Guo, Xingyi; Shu, Xiao‐Ou; Cai, Qiuyin; Shu, Xiang; Li, Bingshan; Tao, Ran; Wu, Chong; B. Nikas, Jason; Sun, Yanfa; Zhu, Jingjing; J. Roobol, Monique; G. Giles, Graham; Brenner, Hermann; M. John, Esther; A. Clements, Judith; Marie Grindedal, Eli; Y. Park, Jong; L. Stanford, Janet; Kote‐Jarai, Zsofia; A. Haiman, Christopher; A. Eeles, Rosalind; Zheng, Wei; Long, Jirong; A. Eeles, Rosalind; E. Henderson, Brian; A. Haiman, Christopher; Kote‐Jarai, Zsofia; R. Schumacher, Fredrick; F. Easton, Douglas; Benlloch, Sara; Amin Al Olama, Ali; Muir, Kenneth; I. Berndt, Sonja; V. Conti, David; Wiklund, Fredrik; J. Chanock, Stephen; M. Gapstur, Susan; L. Stevens, Victoria; M. Tangen, Catherine; Batra, Jyotsna; A. Clements, Judith; Grönberg, Henrik; Pashayan, Nora; Schleutker, Johanna; Albanes, Demetrius; J. Weinstein, Stephanie; Wolk, Alicja; West, Catharine; A. Mucci, Lorelei; Cancel‐Tassin, Géraldine; Koutros, Stella; D. Sørensen, Karina; Marie Grindedal, Eli; E. Neal, David; C. Hamdy, Freddie; Donovan, Jenny; C. Travis, Ruth; J. Hamilton, Robert; A. Ingles, Sue; S. Rosenstein, Barry; Lu, Yong‐Jie; G. Giles, Graham; S. Kibel, Adam; Vega, Ana; Kogevinas, Manolis; L. Penney, Kathryn; Y. Park, Jong; L. Stanford, Janet; Cybulski, Cezary; G. Nordestgaard, Børge; Brenner, Hermann; Maier, Christiane; Kim, Jeri; M. John, Esther; R. Teixeira, Manuel; L. Neuhausen, Susan; De Ruyck, Kim; Hassan Abdul Razack, Azad; F. Newcomb, Lisa; Gamulin, Marija; Kaneva, Radka; Usmani, Nawaid; Claessens, Frank; A. Townsend, Paul; Gago Dominguez, Manuela; J. Roobol, Monique; Ménégaux, F.; Khaw, Kay‐Tee; Cannon‐Albright, Lisa; Pandha, Hardev; N. Thibodeau, Stephen; J. Hunter, David; J. Blot, William; Ríboli, Elio; A. Eeles, Rosalind; Kote‐Jarai, Zsofia; West, Catharine; E. Neal, David; C. Hamdy, Freddie; Donovan, Jenny; C. Travis, Ruth; Ríboli, Elio; E. Henderson, Brian; A. Haiman, Christopher; R. Schumacher, Fredrick; I. Berndt, Sonja; J. Chanock, Stephen; M. Gapstur, Susan; L. Stevens, Victoria; Albanes, Demetrius; J. Weinstein, Stephanie; A. Mucci, Lorelei; Koutros, Stella; C. Travis, Ruth; L. Penney, Kathryn; J. Hunter, David; Ríboli, Elio; Wiklund, Fredrik; Grönberg, Henrik; I. Berndt, Sonja; J. Chanock, Stephen; Albanes, Demetrius; J. Weinstein, Stephanie; Koutros, Stella

doi:10.1038/s41467-020-17673-9

Public

An integrative multi-omics analysis to identify candidate DNA methylation biomarkers related to prostate cancer risk

Published in Nature Communications • Aug 6, 2020

Authors:

Lang Wu

Yaohua Yang

Xingyi Guo

Abstract

It remains elusive whether some of the associations identified in genome-wide association studies of prostate cancer (PrCa) may be due to regulatory effects of genetic variants on CpG sites, which may further influence expression of PrCa target genes. To search for CpG sites associated with PrCa ris...

Subject

DNA methylation

Prostate cancer

Omics

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