A molecular pore spans the double membrane of the coronavirus replication organelle

Wolff, Georg; W.A.L. Limpens, Ronald; C. Zevenhoven-Dobbe, Jessika; Laugks, Ulrike; Zheng, Shawn; W. M. de Jong, Anja; I. Koning, Roman; A. Agard, David; Grünewald, Kay; J. Koster, Abraham; J. Snijder, Eric; Bárcena, Montserrat

doi:10.1126/science.abd3629

Public

A molecular pore spans the double membrane of the coronavirus replication organelle

Published in Science • Aug 6, 2020

Authors:

Georg Wolff

Ronald W.A.L. Limpens

Jessika C. Zevenhoven-Dobbe

Abstract

Coronavirus genome replication is associated with virus-induced cytosolic double-membrane vesicles, which may provide a tailored microenvironment for viral RNA synthesis in the infected cell. However, it is unclear how newly synthesized genomes and messenger RNAs can travel from these sealed replica...

Subject

Replication (statistics)

Organelle

Coronavirus

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