Preclinical evidence for the therapeutic value of TBX5 normalization in arrhythmia control

S Rathjens, Franziska; Blenkle, Alica; M Iyer, Lavanya; Renger, Anke; Syeda, Fahima; Noack, Claudia; Jungmann, Andreas; Dewenter, Matthias; Toischer, Karl; El‐Armouche, Ali; J. Müller, Oliver; Fabritz, Larissa; Zimmermann, Wolfram‐Hubertus; C. Zelarayán, Laura; Zafeiriou, Maria-Patapia

doi:10.1093/cvr/cvaa239

Public

Preclinical evidence for the therapeutic value of TBX5 normalization in arrhythmia control

Published in Cardiovascular Research • Aug 4, 2020

Authors:

Franziska S Rathjens

Alica Blenkle

Lavanya M Iyer

Abstract

AIMS: Arrhythmias and sudden cardiac death (SCD) occur commonly in patients with heart failure. We found T-box 5 (TBX5) dysregulated in ventricular myocardium from heart failure patients and thus we hypothesized that TBX5 reduction contributes to arrhythmia development in these patients. To understa...

Subject

Heart failure

Medicine

Cardiology

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