Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapy

F. Mager, Lukas; Burkhard, Regula; Pett, Nicola; C.A. Cooke, Noah; Brown, Kirsty; R. Ramay, Hena; Paik, Seungil; Stagg, John; A. Groves, Ryan; Gallo, Marco; A. Lewis, Ian; B. Geuking, Markus; D. McCoy, Kathy

doi:10.1126/science.abc3421

Public

Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapy

Published in Science • Aug 13, 2020

Authors:

Lukas F. Mager

Regula Burkhard

Nicola Pett

Abstract

Inosine modulates antitumor immunity Checkpoint blockade immunotherapy harnesses the immune system to kill cancer cells and has been used with great success to treat certain tumors, but not all cancer patients respond. The efficacy of checkpoint blockade immunotherapy has been shown to depend on the...

Subject

Inosine

Immunotherapy

Microbiome

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