Prognostic and Predictive Impact of Circulating Tumor DNA in Patients with Advanced Cancers Treated with Immune Checkpoint Blockade

Zhang, Qu; Luo, Jia; Wu, Song; Si, Han; Gao, Chen; Xu, Wenjing; E. Abdullah, Shaad; W. Higgs, Brandon; A. Dennis, Phillip; S. van der Heijden, Michiel; H. Segal, Neil; E. Chaft, Jamie; Hembrough, Todd; Carl Barrett, J.; D. Hellmann, Matthew

doi:10.1158/2159-8290.cd-20-0047

Public

Prognostic and Predictive Impact of Circulating Tumor DNA in Patients with Advanced Cancers Treated with Immune Checkpoint Blockade

Published in Cancer Discovery • Aug 14, 2020

Authors:

Qu Zhang

Jia Luo

Song Wu

Abstract

Abstract The utility of circulating tumor DNA (ctDNA) as a biomarker in patients with advanced cancers receiving immunotherapy is uncertain. We therefore analyzed pretreatment (n = 978) and on-treatment (n = 171) ctDNA samples across 16 advanced-stage tumor types from three phase I/II trials of durv...

Subject

Blockade

Immune checkpoint

Medicine

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