Validation of Serum Neurofilament Light Chain as a Biomarker of Parkinson's Disease Progression

Mollenhauer, Brit; Dakna, Mohammed; Kruse, Niels; Galasko, Douglas; Foroud, Tatiana; Zetterberg, Henrik; Schade, Sebastian; G. Gera, Roland; Wang, Wenting; Gao, Feng; Frasier, Mark; M. Chahine, Lana; S. Coffey, Christopher; Singleton, Andrew; Simuni, Tanya; Weintraub, Daniel; Seibyl, John; W. Toga, Arthur; M. Tanner, Caroline; Kieburtz, Karl; Marek, Kenneth; Siderowf, Andrew; M. Cedarbaum, Jesse; J. Hutten, Samantha; Trenkwalder, Claudia; Graham, Danielle

doi:10.1002/mds.28206

Public

Validation of Serum Neurofilament Light Chain as a Biomarker of Parkinson's Disease Progression

Published in Movement Disorders • Aug 15, 2020

Authors:

Brit Mollenhauer

Mohammed Dakna

Niels Kruse

Abstract

BACKGROUND: The objective of this study was to assess neurofilament light chain as a Parkinson's disease biomarker. METHODS: We quantified neurofilament light chain in 2 independent cohorts: (1) longitudinal cerebrospinal fluid samples from the longitudinal de novo Parkinson's disease cohort and (2)...

Subject

Biomarker

Parkinson's disease

Cohort

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