Rucaparib in Men With Metastatic Castration-Resistant Prostate Cancer Harboring a
                    <i>BRCA1</i>
                    or
                    <i>BRCA2</i>
                    Gene Alteration

Abida, Wassim; Patnaik, Akash; Campbell, David; Shapiro, Jeremy; H. Bryce, Alan; McDermott, Ray; Sautois, Brieuc; J. Vogelzang, Nicholas; M. Bambury, Richard; Voog, Eric; Zhang, Jingsong; M. Piulats, Josep; J. Ryan, Charles; S. Merseburger, Axel; Daugaard, Gedske; Heidenreich, Axel; Fizazi, Karim; S. Higano, Celestia; E. Krieger, Laurence; N. Sternberg, Cora; P. Watkins, Simon; Despain, Darrin; D. Simmons, Andrew; Loehr, Andrea; Dowson, Melanie; Golsorkhi, Tony; Chowdhury, Simon; behalf of the TRITON2 investigators, on

doi:10.1200/jco.20.01035

Public

Rucaparib in Men With Metastatic Castration-Resistant Prostate Cancer Harboring a BRCA1 or BRCA2 Gene Alteration

Shared by NobleBlocks on Nov 10, 2020 • 12:00 AM UTC

Authors:

Wassim Abida

Akash Patnaik

David Campbell

Abstract

PURPOSE BRCA1 or BRCA2 ( BRCA) alterations are common in men with metastatic castration-resistant prostate cancer (mCRPC) and may confer sensitivity to poly(ADP-ribose) polymerase inhibitors. We present results from patients with mCRPC associated with a BRCA alteration treated with rucaparib 600 mg ...

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