Cancer-Associated Fibroblasts Induce Epithelial-Mesenchymal Transition and Cisplatin Resistance in Ovarian Cancer via CXCL12/CXCR4 Axis

Zhang, Fang; Cui, Jianying; Gao, Haifeng; Yu, Hao; Gao, Fufeng; Chen, Jinlong; Chen, Liang

doi:10.2217/fon-2020-0095

Public

Cancer-Associated Fibroblasts Induce Epithelial-Mesenchymal Transition and Cisplatin Resistance in Ovarian Cancer via CXCL12/CXCR4 Axis

Published in Future Oncology • Aug 17, 2020

Authors:

Fang Zhang

Jianying Cui

Haifeng Gao

Abstract

Aim: Cancer-associated fibroblasts (CAFs) are closely related to epithelial-mesenchymal transition (EMT) and chemoresistance in various cancers. Patients & methods: Experiments in vivo and retrospective studies were applied to explore the role of CAFs in epithelial ovarian cancer (EOC). Results: We ...

Subject

Epithelial–mesenchymal transition

Medicine

Ovarian cancer

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