Talazoparib versus chemotherapy in patients with germline BRCA1/2-mutated HER2-negative advanced breast cancer: final overall survival results from the EMBRACA trial

K. Litton, Jennifer; A. Hurvitz, Sara; A. Mina, Lida; S. Rugo, Hope; Hoon Lee, Ki; Gonçalvès, Anthony; Diab, Sami; Woodward, Natasha; Goodwin, Annabel; Yerushalmi, Rinat; Roché, Henri; Im, Young‐Hyuck; Eiermann, W.; G.W. Quek, Ruben; Usari, Tiziana; Lanzalone, Silvana; Czibere, Akos; L. Blum, Joanne; Martín, Miguel; Ettl, Johannes

doi:10.1016/j.annonc.2020.08.2098

Public

Talazoparib versus chemotherapy in patients with germline BRCA1/2-mutated HER2-negative advanced breast cancer: final overall survival results from the EMBRACA trial

Published in Annals of Oncology • Aug 20, 2020

Authors:

Jennifer K. Litton

Sara A. Hurvitz

Lida A. Mina

Abstract

•In BRCA1/2-mutated advanced breast cancer, talazoparib did not significantly improve overall survival (OS) versus chemotherapy.•OS was generally consistent across subgroups including by prior platinum, hormone-receptor status, or line of treatment.•Most patients received subsequent systemic treatme...

Subject

Medicine

Hazard ratio

Chemotherapy

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