The role of IL-1β and TNF-α in intervertebral disc degeneration

Wang, Yongjie; Che, Mingxue; Xin, Jingguo; Zheng, Zhi; Li, Jiangbi; Zhang, Shaokun

doi:10.1016/j.biopha.2020.110660

Public

The role of IL-1β and TNF-α in intervertebral disc degeneration

Published in Biomedicine & Pharmacotherapy • Aug 24, 2020

Authors:

Yongjie Wang

Mingxue Che

Jingguo Xin

Abstract

Low back pain (LBP), a prevalent and costly disease around the world, is predominantly caused by intervertebral disc (IVD) degeneration (IDD). LBP also presents a substantial burden to public health and the economy. IDD is mainly caused by aging, trauma, genetic susceptibility, and other factors. It...

Subject

Proinflammatory cytokine

Pyroptosis

Intervertebral disc

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