Urine DNA methylation assay enables early detection and recurrence monitoring for bladder cancer

Chen, Xu; Zhang, Jingtong; Ruan, Weimei; Huang, Ming; Wang, Chanjuan; Wang, Hong; Jiang, Zeyu; Wang, Shaogang; Liu, Zheng; Liu, Chunxiao; Tan, Wanlong; Yang, Jin; Chen, Jiaxin; Chen, Zhiwei; Li, Xia; Zhang, Xiaoyu; Xu, Peng; Chen, Lin; Xie, Ruihui; Zhou, Qianghua; Xu, Shizhong; Irwin, Darryl; Fan, Jian‐Bing; Huang, Jian; Lin, Tianxin

doi:10.1172/jci139597

Public

Urine DNA methylation assay enables early detection and recurrence monitoring for bladder cancer

Published in Journal of Clinical Investigation • Aug 20, 2020

Authors:

Xu Chen

Jingtong Zhang

Weimei Ruan

Abstract

BACKGROUNDCurrent methods for the detection and surveillance of bladder cancer (BCa) are often invasive and/or possess suboptimal sensitivity and specificity, especially in early-stage, minimal, and residual tumors.METHODSWe developed an efficient method, termed utMeMA, for the detection of urine tu...

Subject

Bladder cancer

DNA methylation

Methylation

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