p53 activation during ribosome biogenesis regulates normal erythroid differentiation.

Goff S, Le; I, Boussaid; C, Floquet; A, Raimbault; I, Hatin; C, Andrieu-Soler; M, Salma; M, Leduc; EF, Gautier; B, Guyot; D, d'Allard; N, Montel-Lehry; S, Ducamp; A, Houvert; F, Guillonneau; S, Giraudier; E, Cramer-Bordé; F, Morlé; JJ, Diaz; O, Hermine; N, Taylor; S, Kinet; F, Verdier; RA, Padua; N, Mohandas; PE, Gleizes; E, Soler; P, Mayeux; M, Fontenay

doi:10.1182/blood.2019003439

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p53 activation during ribosome biogenesis regulates normal erythroid differentiation.

Shared by NobleBlocks on Jan 1, 2021 • 12:00 AM UTC

Authors:

Le Goff S

Boussaid I

Floquet C

Abstract

The role of ribosome biogenesis in erythroid development is supported by the recognition of erythroid defects in ribosomopathies in both Diamond-Blackfan anemia and 5q- syndrome. Whether ribosome biogenesis exerts a regulatory function on normal erythroid development is still unknown. In the present...

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