Cross-reactivity between tumor MHC class I–restricted antigens and an enterococcal bacteriophage

Fluckiger, Aurélie; Daillère, Romain; Sassi, Mohamed; S. Sixt, Barbara; Liu, Peng; Loos, Friedemann; Richard, Corentin; Rabu, Catherine; Tidjani Alou, Maryam; Goubet, Anne‐Gaëlle; Lemaître, Fabien; Ferrere, Gladys; Derosa, Lisa; P.M. Duong, Connie; Messaoudene, Meriem; Gagné, Andréanne; Joubert, Philippe; De Sordi, Luisa; Debarbieux, Laurent; Simon, Sylvain; Scarlata, Clara‐Maria; Ayyoub, Maha; Palermo, Belinda; Facciolo, Francesco; Boidot, Romain; Wheeler, Richard; G. Boneca, Ivo; Sztupinszki, Zsófia; Papp, Krisztián; Csabai, István; Pasolli, Edoardo; Segata, Nicola; López-Otı́n, Carlos; Szállási, Zoltán; André, Fabrice; Iebba, Valerio; Quiniou, Valentin; Klatzmann, David; Bou Khalil, Jacques; Khelaifia, S.; Raoult, Didier; Albigès, Laurence; Escudier, Bernard; Eggermont, Alexander; Mami‐Chouaib, Fathia; Nisticò, Paola; Ghiringhelli, François; Routy, Bertrand; Labarrière, Nathalie; Cattoir, Vincent; Kroemer, Guido; Zitvogel, Laurence

doi:10.1126/science.aax0701

Public

Cross-reactivity between tumor MHC class I–restricted antigens and an enterococcal bacteriophage

Published in Science • Aug 21, 2020

Authors:

Aurélie Fluckiger

Romain Daillère

Mohamed Sassi

Abstract

Phages and cancer immunity Gut bacteria are involved in the education of T cell immune responses, and the intestinal ecosystem influences anticancer immunity. Fluckiger et al. report microbial antigens that might cross-react with antigens associated with tumor cells. They found that a type of intest...

Subject

Bacteriophage

Immune system

Antigen

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