The Gut Microbiome Is Associated with Clinical Response to Anti–PD-1/PD-L1 Immunotherapy in Gastrointestinal Cancer

Peng, Zhi; Cheng, Siyuan; Kou, Yan; Wang, Ziqi; Jin, Rong; Han, Hu; Zhang, Xiaotian; Gong, Jifang; Li, Jian; Lu, Ming; Wang, Xicheng; Zhou, Jun; Lü, Zhihao; Zhang, Quan; T.W. Tzeng, David; Bi, Dongtao; Tan, Yan; Shen, Lin

doi:10.1158/2326-6066.cir-19-1014

Public

The Gut Microbiome Is Associated with Clinical Response to Anti–PD-1/PD-L1 Immunotherapy in Gastrointestinal Cancer

Published in Cancer Immunology Research • Aug 27, 2020

Authors:

Zhi Peng

Siyuan Cheng

Yan Kou

Abstract

Abstract We report on a comprehensive analysis of the gut microbiomes of patients with gastrointestinal (GI) cancer receiving anti–PD-1/PD-L1 treatment. The human gut microbiota has been associated with clinical responses to anti–PD-1/PD-L1 immunotherapy in melanoma, non–small cell lung cancer, and ...

Subject

Immunotherapy

Gastrointestinal cancer

Medicine

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