An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction

Hanke, Leo; Perez Vidakovics, Laura; J. Sheward, Daniel; Das, Hrishikesh; Schulte, Tim; Moliner Morro, Ainhoa; Corcoran, Martin; Achour, Adnane; B. Karlsson Hedestam, Gunilla; Hallberg, B.M.; Murrell, Ben; M. McInerney, Gerald

doi:10.1038/s41467-020-18174-5

Public

An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction

Published in Nature Communications • Sep 4, 2020

Authors:

Leo Hanke

Laura Perez Vidakovics

Daniel J. Sheward

Abstract

SARS-CoV-2 enters host cells through an interaction between the spike glycoprotein and the angiotensin converting enzyme 2 (ACE2) receptor. Directly preventing this interaction presents an attractive possibility for suppressing SARS-CoV-2 replication. Here, we report the isolation and characterizati...

Subject

Receptor

Cell biology

Glycoprotein

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