CDK4/6 inhibition promotes immune infiltration in ovarian cancer and synergizes with PD-1 blockade in a B cell-dependent manner

Zhang, Qian‐Feng; Li, Jia; Jiang, Kuo; Wang, Rui; Ge, Junli; Yang, Hong; Liu, Shujuan; Jia, Lintao; Wang, Lei; Chen, Biliang

doi:10.7150/thno.44871

Public

CDK4/6 inhibition promotes immune infiltration in ovarian cancer and synergizes with PD-1 blockade in a B cell-dependent manner

Published in Theranostics • Jan 1, 2020

Authors:

Qian‐Feng Zhang

Jia Li

Kuo Jiang

Abstract

These findings suggest that combined treatment with CDK4/6i and anti-PD-1 antibody could improve the efficacy of anti-PD-1 therapy and hold great promise for the treatment of poorly immune-infiltrated ovarian cancer.

Subject

Blockade

Cancer research

Immune system

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