Pervasive chromosomal instability and karyotype order in tumour evolution

B.K. Watkins, Thomas; L. Lim, Emilia; Petković, Marina; Elizalde, Sergi; J. Birkbak, Nicolai; A. Wilson, Gareth; A. Moore, David; Grönroos, Eva; Rowan, Andrew; M. Dewhurst, Sally; Demeulemeester, Jonas; C. Dentro, Stefan; Horswell, Stuart; Au, Lewis; Haase, Kerstin; Escudero, Mickael; Rosenthal, Rachel; Al Bakir, Maise; Xu, Hang; Litchfield, Kevin; Lu, Wei-Ting; P. Mourikis, Thanos; Dietzen, Michelle; Spain, Lavinia; D. Cresswell, George; Biswas, Dhruva; Lamy, Philippe; Nordentoft, Iver; Harbst, Katja; Castro-Giner, Francesc; Yates, Lucy; Caramia, Franco; Jaulin, Fanny; Vicier, Cécile; Tomlinson, Ian; K. Brastianos, Priscilla; J. Cho, Raymond; C. Bastian, Boris; Dyrskjøt, Lars; Jönsson, Göran; Savas, Peter; Loi, Sherene; J. Campbell, Peter; André, Fabrice; M. Luscombe, Nicholas; Steeghs, Neeltje; C. G. Tjan‐Heijnen, Vivianne; Szállási, Zoltán; Turajlic, Samra; Jamal‐Hanjani, Mariam; Van Loo, Peter; F. Bakhoum, Samuel; F. Schwarz, Roland; McGranahan, Nicholas; Swanton, Charles

doi:10.1038/s41586-020-2698-6

Public

Pervasive chromosomal instability and karyotype order in tumour evolution

Published in Nature • Sep 2, 2020

Authors:

Thomas B.K. Watkins

Emilia L. Lim

Marina Petković

Abstract

Chromosomal instability in cancer consists of dynamic changes to the number and structure of chromosomes1,2. The resulting diversity in somatic copy number alterations (SCNAs) may provide the variation necessary for tumour evolution1,3,4. Here we use multi-sample phasing and SCNA analysis of 1,421 s...

Subject

Karyotype

Chromosome instability

Genome instability

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