Impact and consequences of intensive chemotherapy on intestinal barrier and microbiota in acute myeloid leukemia: the role of mucosal strengthening

Hueso, Thomas; Ekpe, Kenneth; Mayeur, Camille; Gatse, Anna; Joncquel-Chevalier Curt, Marie; Gricourt, Guillaume; Rodriguez, Christophe; Burdet, Charles; Ulmann, Guillaume; Neut, Christel; Amini, Salah-Eddine; Lepage, Patricia; Raynard, Bruno; Willekens, Christophe; Micol, Jean‐Baptiste; de Botton, Stéphane; Yakoub‐Agha, Ibrahim; Gottrand, Frédèric; Desseyn, Jean‐Luc; Thomas, Muriel; Woerther, Paul‐Louis; Séguy, D.

doi:10.1080/19490976.2020.1800897

Public

Impact and consequences of intensive chemotherapy on intestinal barrier and microbiota in acute myeloid leukemia: the role of mucosal strengthening

Published in Gut Microbes • Sep 6, 2020

Authors:

Thomas Hueso

Kenneth Ekpe

Camille Mayeur

Abstract

Induction chemotherapy (7 + 3 regimen) remains the gold standard for patients with acute myeloid leukemia (AML) but is responsible for gut damage leading to several complications such as bloodstream infection (BSI). We aimed to investigate the impact of induction chemotherapy on the intestinal barri...

Subject

Biology

Myeloid leukemia

Dysbiosis

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