Head-to-head comparison of DFO* and DFO chelators: selection of the best candidate for clinical <sup>89</sup>Zr-immuno-PET.

M, Chomet; M, Schreurs; MJ, Bolijn; M, Verlaan; W, Beaino; K, Brown; AJ, Poot; AD, Windhorst; H, Gill; J, Marik; S, Williams; J, Cowell; G, Gasser; TL, Mindt; Dongen GAMS, van; DJ, Vugts

doi:10.1007/s00259-020-05002-7

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Head-to-head comparison of DFO* and DFO chelators: selection of the best candidate for clinical 89Zr-immuno-PET.

Shared by NobleBlocks on Sep 5, 2020 • 12:00 AM UTC

Authors:

Chomet M

Schreurs M

Bolijn MJ

Abstract

Purpose Almost all radiolabellings of antibodies with 89Zr currently employ the hexadentate chelator desferrioxamine (DFO). However, DFO can lead to unwanted uptake of 89Zr in bones due to instability of the resulting metal complex. DFO*-NCS and the squaramide ester of DFO, DFOSq, are novel analogue...

Subject

Dfo

89Zr-immuno-pet

Dfo*

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