Culture of rabbit caecum organoids by reconstituting the intestinal stem cell niche in vitro with pharmacological inhibitors or L-WRN conditioned medium

Mussard, Eloïse; Pouzet, Cécile; Héliès, Virginie; Pascal, Géraldine; Fourré, Sandra; Cherbuy, Claire; Rubio, Aude; Vergnolle, Nathalie; Combes, Sylvie; Beaumont, Martín

doi:10.1016/j.scr.2020.101980

Public

Culture of rabbit caecum organoids by reconstituting the intestinal stem cell niche in vitro with pharmacological inhibitors or L-WRN conditioned medium

Published in Stem Cell Research • Sep 4, 2020

Authors:

Eloïse Mussard

Cécile Pouzet

Virginie Héliès

Abstract

Intestinal organoids are self-organized 3-dimensional (3D) structures formed by a single layer of polarized epithelial cells. This innovative in vitro model is highly relevant to study physiology of the intestinal epithelium and its role in nutrition and barrier function. However, this model has nev...

Subject

Organoid

Biology

Cell biology

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