Mast cells as a unique hematopoietic lineage and cell system: From Paul Ehrlich's visions to precision medicine concepts

Valent, Peter; Akin, Cem; Hartmann, Karin; Nilsson, Gunnar; Reiter, Andreas; Hermine, Olivier; Sotlar, Karl; R. Sperr, Wolfgang; Escribano, Luís; I. George, Tracy; C. Kluin‐Nelemans, Hanneke; Üstün, Celalettin; Triggiani, Massimo; Brockow, Knut; Gotlib, Jason; Órfão, Alberto; T. Kovanen, Petri; Hadzijusufovic, Emir; Sadovnik, Irina; Horny, Hans‐Peter; Arock, Michel; B. Schwartz, Lawrence; Frank Austen, K.; D. Metcalfe, Dean; J. Galli, Stephen

doi:10.7150/thno.46719

Public

Mast cells as a unique hematopoietic lineage and cell system: From Paul Ehrlich's visions to precision medicine concepts

Published in Theranostics • Jan 1, 2020

Authors:

Peter Valent

Cem Akin

Karin Hartmann

Abstract

The origin and functions of mast cells (MCs) have been debated since their description by Paul Ehrlich in 1879. MCs have long been considered 'reactive bystanders' and 'amplifiers' in inflammatory processes, allergic reactions, and host responses to infectious diseases. However, knowledge about the ...

Subject

Haematopoiesis

Phenotype

Biology

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