Arctigenin protects against depression by inhibiting microglial activation and neuroinflammation via HMGB1/TLR4/NF‐κB and TNF‐α/TNFR1/NF‐κB pathways

Xu, Xiang; Piao, Hu‐Nan; Aosai, Fumie; Zeng, Xiao‐Yu; Cheng, Jiahui; Cui, Yue‐Xian; Li, Jing; Ma, Juan; Piao, Hu‐Ri; Jin, Xuejun; Xun Piao, Lian

doi:10.1111/bph.15261

Public

Arctigenin protects against depression by inhibiting microglial activation and neuroinflammation via HMGB1/TLR4/NF‐κB and TNF‐α/TNFR1/NF‐κB pathways

Published in British Journal of Pharmacology • Sep 28, 2020

Authors:

Xiang Xu

Hu‐Nan Piao

Fumie Aosai

Abstract

BACKGROUND AND PURPOSE: Arctigenin, a major bioactive component of Fructus arctii, has been reported to have antidepressant-like effects. However, the mechanisms underlying these effects are still unclear. Neuroinflammation can be caused by excessive production of proinflammatory cytokines in microg...

Subject

Neuroinflammation

TLR4

HMGB1

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