Arctigenin protects against depression by inhibiting microglial activation and neuroinflammation via HMGB1/TLR4/NF‐κB and TNF‐α/TNFR1/NF‐κB pathways

Xu, Xiang; Piao, Hu‐Nan; Aosai, Fumie; Zeng, Xiao‐Yu; Cheng, Jia‐Hui; Cui, Yue‐Xian; Li, Jing; Ma, Juan; Piao, Hu‐Ri; Jin, Xuejun; Piao, Lian‐Xun

doi:10.1111/bph.15261

Public

Arctigenin protects against depression by inhibiting microglial activation and neuroinflammation via HMGB1/TLR4/NF‐κB and TNF‐α/TNFR1/NF‐κB pathways

Shared by NobleBlocks on Oct 19, 2020 • 12:00 AM UTC

Authors:

Xiang Xu

Hu‐Nan Piao

Fumie Aosai

Abstract

Background and Purpose Arctigenin, a major bioactive component of Fructus arctii , has been reported to have antidepressant‐like effects. However, the mechanisms underlying these effects are still unclear. Neuroinflammation can be caused by excessive production of proinflammatory cytokines in microg...

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