MFG-E8 accelerates wound healing in diabetes by regulating “NLRP3 inflammasome-neutrophil extracellular traps” axis

Huang, Wei; Jiao, Jinyu; Liu, Ju; Huang, Meng; Hu, Yanyan; Ran, Wenzhuo; Li, Yan; Xiong, Yin; Mei, Li; Quan, Ziyao; Rao, Yahua; Chen, Jiayi; Huang, Yan; Zhang, Dongxin

doi:10.1038/s41420-020-00318-7

Public

MFG-E8 accelerates wound healing in diabetes by regulating “NLRP3 inflammasome-neutrophil extracellular traps” axis

Published in Cell Death Discovery • Sep 10, 2020

Authors:

Wei Huang

Jinyu Jiao

Ju Liu

Abstract

Abstract Sustained activation of NLRP3 inflammasome and release of neutrophil extracellular traps (NETs) impair wound healing of diabetic foot ulcers (DFUs). Our previous study reported that milk fat globule epidermal growth factor VIII (MFG-E8) attenuates tissue damage in systemic lupus erythematos...

Subject

Inflammasome

Neutrophil extracellular traps

Wound healing

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