Effect of Out-of-Hospital Tranexamic Acid vs Placebo on 6-Month Functional Neurologic Outcomes in Patients With Moderate or Severe Traumatic Brain Injury

Rowell, Susan; N. Meier, Eric; McKnight, Barbara; Kannas, Delores; May, Susanne; Sheehan, Kellie; M. Bulger, Eileen; H. Idris, Ahamed; Christenson, Jim; J. Morrison, Laurie; J. Frascone, Ralph; L. Bosarge, Patrick; Riccardo Colella, M.; A. Johannigman, Jay; A. Cotton, Bryan; Callum, Jeannie; T. McMullan, Jason; J. Dries, David; Tibbs, Brian; J. Richmond, Neal; L. Weisfeldt, Myron; M. Tallon, John; S. Garrett, John; D. Zielinski, Martin; P. Aufderheide, Tom; R. Gandhi, Rajesh; Schlamp, Rob; R. H. Robinson, Bryce; Jui, Jonathan; R. Klein, Lauren; Rizoli, Sandro; Gamber, Mark; Fleming, Michael; Seong Hwang, Jun; Vincent, Laura; Williams, Carolyn; Hendrickson, Audrey; J Simonson, Robert; Klotz, Patricia; Sopko, George; R. Witham, William; J. Ferrara, Michael; A. Schreiber, Martin

doi:10.1001/jama.2020.8958

Public

Effect of Out-of-Hospital Tranexamic Acid vs Placebo on 6-Month Functional Neurologic Outcomes in Patients With Moderate or Severe Traumatic Brain Injury

Published in JAMA • Sep 8, 2020

Authors:

Susan Rowell

Eric N. Meier

Barbara McKnight

Abstract

Importance: Traumatic brain injury (TBI) is the leading cause of death and disability due to trauma. Early administration of tranexamic acid may benefit patients with TBI. Objective: To determine whether tranexamic acid treatment initiated in the out-of-hospital setting within 2 hours of injury impr...

Subject

Medicine

Tranexamic acid

Glasgow Coma Scale

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