DNA fragmentation of sperm: a radical examination of the contribution of oxidative stress and age in 16 945 semen samples

A. Vaughan, Denis; Tirado, E.E.; García, Désirée; Datta, V.; Sakkas, Denny

doi:10.1093/humrep/deaa159

Public

DNA fragmentation of sperm: a radical examination of the contribution of oxidative stress and age in 16 945 semen samples

Published in Human Reproduction • Jun 9, 2020

Authors:

Denis A. Vaughan

E.E. Tirado

Désirée García

Abstract

STUDY QUESTION: What is the relationship between sperm DNA fragmentation and oxidative stress (OS) with increasing male age? SUMMARY ANSWER: Sperm DNA fragmentation increases with age and is likely related to both defective spermatogenesis and increasing OS levels. WHAT IS KNOWN ALREADY: Sperm quali...

Subject

DNA fragmentation

Sperm

Semen

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