C11orf95-RELA reprograms 3D epigenome in supratentorial ependymoma.

Jufen Zhu, Jacqueline; Jillette, Nathaniel; Li, Xiao-Nan; Wu Cheng, Albert; C Lau, Ching

doi:10.1007/s00401-020-02225-8

Public

C11orf95-RELA reprograms 3D epigenome in supratentorial ependymoma.

Shared by NobleBlocks on Dec 1, 2020 • 12:00 AM UTC

Authors:

Jacqueline Jufen Zhu

Nathaniel Jillette

Xiao-Nan Li

Abstract

Supratentorial ependymoma (ST-EPN) is a type of malignant brain tumor mainly seen in children. Since 2014, it has been known that an intrachromosomal fusion C11orf95-RELA is an oncogenic driver in ST-EPN [Parker et al. Nature 506:451-455 (2014); Pietsch et al. Acta Neuropathol 127:609-611 (2014)] bu...

Subject

3D genome

C11orf95-RELA

Supratentorial ependymoma

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