MT1DP loaded by folate-modified liposomes sensitizes erastin-induced ferroptosis via regulating miR-365a-3p/NRF2 axis in non-small cell lung cancer cells

Gai, Chengcheng; Liu, Chuanliang; Wu, Xinghan; Yu, Mengyu; Zheng, Jie; Zhang, Weifen; Lv, Shijun; Li, Wentong

doi:10.1038/s41419-020-02939-3

Public

MT1DP loaded by folate-modified liposomes sensitizes erastin-induced ferroptosis via regulating miR-365a-3p/NRF2 axis in non-small cell lung cancer cells

Published in Cell Death and Disease • Sep 14, 2020

Authors:

Chengcheng Gai

Chuanliang Liu

Xinghan Wu

Abstract

Although ferroptosis has been recognized as a novel antitumoral treatment, high expression of nuclear factor erythroid 2-related factor 2 (NRF2) has been reported to be an antioxidant transcript factor that protects malignant cells from ferroptosis. Previous findings indicated that metallothionein 1...

Subject

Downregulation and upregulation

Cancer cell

A549 cell

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