RAB31 marks and controls an ESCRT-independent exosome pathway

Wei, Denghui; Zhan, Weixiang; Gao, Ying; Huang, Liyan; Gong, Run; Wang, Wen; Zhang, Ruhua; Wu, Yuanzhong; Gao, Song; Kang, Tiebang

doi:10.1038/s41422-020-00409-1

Public

RAB31 marks and controls an ESCRT-independent exosome pathway

Published in Cell Research • Sep 21, 2020

Authors:

Denghui Wei

Weixiang Zhan

Ying Gao

Abstract

Exosomes are generated within the multivesicular endosomes (MVEs) as intraluminal vesicles (ILVs) and secreted during the fusion of MVEs with the cell membrane. The mechanisms of exosome biogenesis remain poorly explored. Here we identify that RAB31 marks and controls an ESCRT-independent exosome pa...

Subject

ESCRT

Endosome

Microvesicles

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