Free fatty acid binding pocket in the locked structure of SARS-CoV-2 spike protein

Toelzer, Christine; Gupta, Kapil; K.N. Yadav, Sathish; Borucu, Ufuk; D. Davidson, Andrew; Kavanagh Williamson, Maia; K. Shoemark, Deborah; Garzoni, Frédéric; Staufer, Oskar; Milligan, Rachel; Capin, Julien; J. Mulholland, Adrian; P. Spatz, Joachim; J. Fitzgerald, Daniel; Berger, Imre; Schaffitzel, Christiane

doi:10.1126/science.abd3255

Public

Free fatty acid binding pocket in the locked structure of SARS-CoV-2 spike protein

Published in Science • Sep 21, 2020

Authors:

Christine Toelzer

Kapil Gupta

Sathish K.N. Yadav

Abstract

Locking down the SARS-CoV-2 spike Many efforts to develop therapies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are focused on the spike (S) protein trimer that binds to the host receptor. Structures of trimeric S protein show its receptor-binding domain in either an up or a...

Subject

Spike Protein

Spike (software development)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

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