Free fatty acid binding pocket in the locked structure of SARS-CoV-2 spike protein.

Toelzer, Christine; Gupta, Kapil; K N Yadav, Sathish; Borucu, Ufuk; D Davidson, Andrew; Kavanagh Williamson, Maia; K Shoemark, Deborah; Garzoni, Frederic; Staufer, Oskar; Milligan, Rachel; Capin, Julien; J Mulholland, Adrian; Spatz, Joachim; Fitzgerald, Daniel; Berger, Imre; Schaffitzel, Christiane

doi:10.1126/science.abd3255

Public

Free fatty acid binding pocket in the locked structure of SARS-CoV-2 spike protein.

Published in Science (New York, N.Y.) • Nov 6, 2020

NobleIDark:/48914/w1/20260526/CD93A67DRecord on NobleID

Authors:

Christine Toelzer

,

Kapil Gupta

,

Sathish K N Yadav

Abstract

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), represents a global crisis. Key to SARS-CoV-2 therapeutic development is unraveling the mechanisms that drive high infectivity, broad tissue tropism, and severe pathology. Our 2.85-angstrom c...

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