Avelumab Maintenance Therapy for Advanced or Metastatic Urothelial Carcinoma

Powles, Thomas; Hoon Park, Se; Voog, Éric; Caserta, Claudia; P. Valderrama, Begoña; Gurney, Howard; P. Kalofonos, Haralabos; Radulović, Siniša; Demey, Wim; Ullén, Anders; Loriot, Yohann; S. Sridhar, Srikala; Tsuchiya, Norihiko; Kopyltsov, Evgeny; N. Sternberg, Cora; Bellmunt, Joaquim; B. Aragon‐Ching, Jeanny; P. Petrylak, Daniel; J Laliberte, Robert; Wang, Jing; Huang, Bo; B. Davis, Craig; Fowst, Camilla; Costa, Nuno; A. Blake-Haskins, John; di Pietro, Alessandra; Grivas, Petros

doi:10.1056/nejmoa2002788

Public

Avelumab Maintenance Therapy for Advanced or Metastatic Urothelial Carcinoma

Published in New England Journal of Medicine • Sep 18, 2020

Authors:

Thomas Powles

Se Hoon Park

Éric Voog

Abstract

BACKGROUND: Platinum-based chemotherapy is standard-of-care first-line treatment for advanced urothelial carcinoma. However, progression-free survival and overall survival are limited by chemotherapy resistance. METHODS: In a phase 3 trial, we randomly assigned patients with unresectable locally adv...

Subject

Avelumab

Urothelial carcinoma

Metastatic Urothelial Carcinoma

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